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Message: <blockquote data-quote="Illithidbix" data-source="post: 6812274" data-attributes="member: 12283">This seems a perfectly usable house rule, but I can't find a trace of it in the PHB or DMG.The only mention I can find to the concept of a Fumble in combat is a brief mention of "Critical Success or Failure" on page 242, which is entirely upto the DM.The DMG *does* mention on page 258 that if you are *harvesting* poison from a dead or incapacitated poisonous creature and you fail the DC:20 Intelligence (Nature)* check by 5 or more, the character is subjected to the creature's poison.There doesn't seem to be any listed DC for applying poison Nor does it make it clear how many uses a dose of applied poison is good for (I presume one).The players handbook equipment section does list a "basic poison" which you can extrapolate rules for other injury poisons.EDIT: The semi-official Sage Advice Tweets suggest blade venoms are meant to last for 1 minute and for more than one hit. (<a href="http://www.sageadvice.eu/page/2/?s=poison" target="_blank">http://www.sageadvice.eu/page/2/?s=poison</a>)Edit again! The DMG Errata however seems to imply, not not quite specify the opposite... <a href="http://media.wizards.com/2015/downloads/dnd/DMG_Errata.pdf" target="_blank">http://media.wizards.com/2015/downloads/dnd/DMG_Errata.pdf</a></blockquote>