Only in the evil game I'm running do the players have a base of operation. In fact, they have several. The lead rogue with his thieves' guild. The wizard with his secret underground hideout just outside of town. The rogue/assassin with an appartment. The cleric with a secret chapel under an evil noble's manor...
In another game I play in, one of the players is a baron, so he has a small village, and we often return there.
AR