Okay, here's an example of a villain I'd like to produce.
If you've seen Fallen, you get the idea. An Alien Symbiote who travels from Host to Host via touch. He's a telepath/empath, BUT only to the 'host' he's riding. Domination, suggestion, thought penetration, etc etc. If the person he's in dies, he has about ten seconds to grasp a new body; a mammal with atleast a cat-sized body. The persons around must roll vs letting him in.
Or what about a Kinetic Backlash? A character who can create a 'defense'; any physical blow that he's hit with, he absorbs the kinetic energy (the damage), and then can expell the kinetic energy with a touch. He cannot absorb falling damage, and if he doesn't 'release', it will go off internally. Also I imagine there'd be a thresh-hold, so shooting the sucker with a machine gun would eventually 'fill up' his Kinetic energy hold (But its capacity and time limit would increase as he becomes more experienced).
Now, under what system can this be done? I know it can be done in Champions, but what about any others?