orbitalfreak
Explorer
I tend to think in more "eipc scale" terms, so the campaign in my head right now starts in Waterdeep and crosses all the way into Thay.
For a completely political campaign, I'd suggest Waterdeep, since it's large enough to include many many factions. Wilderness settings like the eastern Realms and the desert areas make for good trek-oriented campaigns. Cormyr and the Dale-lands, being populated for a while and with a lot of history behind them, offer a nice blend of politics and adventure, with dungeons able to be sprinkled liberally throughout.
For a completely political campaign, I'd suggest Waterdeep, since it's large enough to include many many factions. Wilderness settings like the eastern Realms and the desert areas make for good trek-oriented campaigns. Cormyr and the Dale-lands, being populated for a while and with a lot of history behind them, offer a nice blend of politics and adventure, with dungeons able to be sprinkled liberally throughout.