Blinded, trying to cast Cloud Kill

[WolverineJon]

Re: "In Front of Me"

As someone once corrected me regarding flanking, there is no facing in 3e. No facing means there is no "in front of me."
Consequently, you couldn't assume to know where something (even an area) was if you couldn't see it.

In this case, I'd probably permit a Listen check with a low DC to get properly oriented towards the general direction of the combat, for the purpose of casing a spell targetted some distance in that direction.