Sooner or later something crops up that gets optimizers/munchins in hot water.
This is a useful point. In the game, optimization also requires focus. If the character can pull off one of a few very specific combinations, they become machines of death. But, usually, there is a cost in that if they can't pull off the combination, they become very sub-optimal.
F'rex, a character highly optimized to make Diplomacy/Persuasion checks. It is all well and good if the character can persuade a guard into selling his own mother to the PC, this means nothing if the target is an automaton or unintelligent, such that it cannot be persuaded.
If a GM chooses to deal with a highly optimized character, one technique to manage is to make these situations rather more common than you'd otherwise expect. Thus forcing the optimized character to take a back seat for a while, to allow other PCs to shine.
Which is, by the way, the major problem I see with highly optimized characters - their tendency to overshadow everyone else. I don't usually care that much about how powerful the characters are, so long as the players are happy with it.