jdrakeh
Front Range Warlock
When was the last time you played Paranoia?
I admit that it has been a while, but I know that when I did play it wasn't completely unordered, unmanageable, chaos.
When was the last time you played Paranoia?
I think it would work fine as a campaign setting, however the main reason for that is this:
The players would never know. They would just assume that, even though noone THEY ever fight is actually human, that it's just because they're adventurers. Your great secret would be protected by the assumptions of the typical D&D campaign: that the PCs are unique special butterflies fighting unusual threats.
Well now it stops being unworkable and becomes pointless. The players are your only audience. If they never know about it, then who is the concept supposed to entertain? Is the DM just going to go giggle to himself after every session when the players complain, "Your plots are getting really repetitive. Seems like every little village is monsters in disguise!"