Henry
Autoexreginated
Well, based on a thread from the rules forum, how about 7,000 poisoned needle rings (from Dragon #316) on the huge tentacle of a 20th level Rogue Kraken? That's 7,000 damage + 4,000D6 CON damage (save for half) as a touch attack. 
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More seriously, mind-blasting Psions (gives the attack against non-psions a +4 to DC) who overlap and stun the party silly in a blind area.
Or, ranged snipers with STR or DEX poison arrows or bolts, on a balcony, who throw down entangling nets to make it easier to hit?

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More seriously, mind-blasting Psions (gives the attack against non-psions a +4 to DC) who overlap and stun the party silly in a blind area.
Or, ranged snipers with STR or DEX poison arrows or bolts, on a balcony, who throw down entangling nets to make it easier to hit?