I wonder what basis for comparison you are using for placing Paizo in some "minor" league not ready for the big time game yet?
They have more employees than most RPG companies, excepting WotC and WotC, as has been pointed out, is much more than RPGs. I wonder how Paizo's numbers stack up against WotC RPG department.
They have the sales. They are, as I'm sure you read earlier, the #2 RPG in the market at the moment. Subject to change, sure, but nothing to be sneezed at.
They most certainly have experience. I doubt there are many RPG companies with more experience in the industry.
I'm pretty sure his comparison is with other 'hobby game' companies; WotC, Games Workshop, FFG, to name three of the big ones. Paizo aren't even close to that size. And incidentally, number two in the market according to ICV2 for printed books across their whole range; I don't think anyone really knows what pdf sales are like across the industry, or how much is sold directly by the companies that do that.
By the way, what is the figure for full-time employees at Paizo?