In my current setting, not only humans are downplayed, but almost all of the humanoid races. It's a primal world where the wild hasn't been, and can't be dominated by humanity, and humanoid settlements must negotiate with elemental, fey and primal spirits to live in harmony with nature instead of against it, and/or reach an agreement with dragons and giant clans for protection and services (for example, a clan of semi-friendly fire giants or a bronze dragon is a formidable force able to scare away almost any menace to a humanoid settlement, and both parties can provide something for the other; fire giants get crops in exange for their protection and occasional metal work, the bronze dragon gets treasure in exange for protection and good weather for the crops).
However, the situation and the setting puts humanoids and humankind in the middle of the power pyramid. They can thrive, and aren't in risk of extinction, but there are so many things avobe them and competing with them that no humanoid race, be it human, dwarf, elf or orc can really get the numbers to become the dominant species. As a result, it gives me a world primal, untamed and dominated by the wild, where the societies that rise are those of the high powered monsters (mainly dragons and giants).