I've been running a Dread game on Halloween for the past 3 years and it's been a hoot!
The first year, I ran my group through an amusement park scenario where an alien presence was mind-controlling certain employees of the park. The tension built very fast as my players ended up suspecting each other and eventually turned against one another (even though they weren't being mind-controlled).
Last year the team played as scientists and military men who were fighting to survive an existing zombie infestation. Whenever any player died, they became a zombie and pulled jenga blocks to attack the other players. Only one player survived at the end of the night, and that was because she ran away and hid.
This year, I'm plagiarizing the fun-sounding "War of the Dead" scenario where my players start a pleasant cruise to the Bahamas that quickly devolves into madness. No spoilers here. The scenario is written for Savage Worlds, but converting any game to Dread is dead simple.

I'll start off the scenario with my players pulling numerous jenga blocks when engaging in contests that are held by the cruise team, such as rock wall climbing, gambling, drinking contests, silly dance contest, etc. After the first night, though, things will get very serious. The icing on the cake will be the handouts: I'll go online and print out actual cruise brochures and deck maps. I expect this to be a lot of fun.
J.