Let's see...
Novels:
Deatgate series (Weiss/Hickman). I doubt the Sartan or Patryn could be PC races, but the setting really rocks for D&D.
Rose of the Prophet series (also Weiss/Hickman). I loved this series, and always wanted to see a D&D campaign based on it.
Dragonlance series (also Weiss/Hickman). Being worked on. Perhaps if its successful they'll start on the previous two?
Book of Swords series (Fred Saberhagen -- probably too low-magic for D&D, but d20 doable).
Larry Niven's "Ringworld". A friggin huge, essentially post-apocalyptic world, but with enough oddities to be fun to explore and RP in. If you actually liked Ringworld Engineers, you could even throw in thousands of humanoid species evolved to fill missing ecological niches (with tons of inter-species sex, w00t).
A few more I can't think of offhand...
TV:
Babylon 5 is a must. A *BIG* must.
Robotech/Macross
Maybe even Transformers d20? Rules to create your own Autobot.... mmmmm
Just as long as there isn't a Buffy, Xena, or Hercules d20...
Survivor d20? nah....
Movies:
Matrix -- pre Neo, hopefully.
Crouching Tiger Hidden Dragon -- or something set in the same chinese mythological era.
hundreds more, just none that are coming to mind offhand.