YES.
I ran Burning Plague from the WotC site for the 2 boys (who have role played 3 or 4 times) and the wife yesterday. They had some real trouble acting like a group (no one had the lead, they didn't know "who" they were...), but they seemed to have fun. My wife is willing to play again, and the oldest, as always, can't wait to play again. My younger son likes to play and wants to play again.
I clearly need to spend some time with my wife about the game, and what her character can and can't do. She spent a lot of time deferring to the boys, which made sense from a parenting perspective, but in game she had some good ideas she didn't push.
We'll certainly play again, though I'm not sure what I'll run next. There are only 3 of them, so I need to throw some healing magic their way. I'm looking at U1, or possibly "of sound Mind" which is an awesome adventure - too bad the followup was never written/released. I may also wait for the next adventure from WotC, or I'm still digging through old Dungeon mags....