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Message: <blockquote data-quote="Nitrosaur" data-source="post: 8660322" data-attributes="member: 7022830">It's very close, but I think Acererak has a better chance of winning? Just with their unalterded statblocks:Mind Blank blocks Vecna's regen and he has no Detect Magic or Identify, so no way of knowing that's up. Vecna can only hurt Ace with a resisted Lightning Bolt, and while Ace cant really cast spells reliably with that fair and balanced™ Dread Counterspell, he can throw arround the Sphere of Annihilation, once on his turn and as a Legendary Action. The save DC is low, but Vecna has no proficiency on the save, so once he burns the LRs, he has a 50/50 chance of making the save. He could try to take over the sphere, but with the Talisman of the Sphere, Ace has a much better chance of controling the sphere than Vecna, and with the extra range provided by the Talisman of the Sphere, Ace should be in a much better and safe position should the sphere momentarily escape his control.So, with a 50/50 chance of taking damage from the sphere that comes twice per round, Vecna is taking an average of 22 unresisted damage on his  272 hp once his 5 LRs run out. He dies on an average of 17 rounds.On average, Acererak isn't making the dex save from Lightning Bolt, but he resists the damage, so he is taking on average 14 damage on his 285 hp. He dies on an average of 21-22 rounds.It's close, but on average, Acererak should win more often than Vecna.</blockquote>