I once played a Goliath gladiator. His schtick in the arena was durability.
I started out with a high constitution and a Barbarian/Fighter mix, took 3 levels of Dwarf (Duergar, actually, which had no mechanical changes) Stoneblessed, and then went into Deepwarden.
He wore Gnomish Twistcloth armor, which doesn't look like much protection at all, and then used his huge Constitution modifier to replace Dex to AC. The Deepwarden doesn't really specify how that trick works, so I explained it as his freakish vitality letting him take serious wounds without even noticing. He actually had a slightly negative Dex modifier, making him as a big hearty guy who happened to break the too-small objects around him by accident.
He was created as an ECL 10 character, and playing him up from level 1 would mean going without the Constitution-to-AC trick for a very long time. I also didn't get to play him for very long, but noticed his comparatively low AC meant he took a lot of damage. Restoring that much damage takes more out of the party healer than a more conventional high-AC type.