Good 2 man teams

[Gregor]

While I agree that the Druid and Rogue are both very versatile, I fear a group of those two PCs might play too much like Angel Summoner and the BMX Bandit.

"One can summon Angels! The other rides a BMX!" Love it. Have you seen the Praise Vectron one? Genius.

Anyway, my suggestion would be Cleric and Rogue.

 

[FEADIN]

Aother option is to have each one play 2 characters, in this case you don't loose the number of actions and it's not very difficult at low and mid level.

 

[Reneshat]

I agree that it matters what the focus of the campaign is. Without knowing what the campaign is at all, I would suggest you don't steer too far away from trying to get a variety of spells, meat, and skills in your combo. Thus, I would suggest either cleric or druid and beguiler. If you don't need to worry about traps or skill checks, any combination of druid and cleric should work (I do like cloistered cleric). If the game is going to be undead focused, cleric/cleric or cleric/paladin teams should do fine.

Of course, there is always gestalt.

 

[Herobizkit]

Cloistered Cleric and Warlock could be all sorts of interesting, flavour-wise... they might not be so hot in melee, however.

Gestalt is still your best bet.