Help me EN World, you're my only hope...

If you choose to continue having her change, just before they get the cure, I say step it up to teh point that she's very concerned. Even if you have no intentions of having her fully change, don't let her know that, make her thing she's about to go over the hump.

You said that this turns them into driders/scorpionfolk, yes? Well, then perhaps she's starting to lose feeling in her legs. They're starting to change color, like they're dying. Or she's getting some serious cramps/feelings of things movign around in her stomach, pushing against her abdomen - the new set of legs ready to come out.
 

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Give her a cool new power related to the transformed abberations and then slowly kill (or change) her, it may give her a bit of pause before taking the cure.

PC Friend: "You can't walk... and you're getting worse... "
Poisoned PC: "I'm getting...*better*! "

Apart from the social penalties of being diseased I would work a disease track, but only have her check at stressful moments - like combat. And have physical transformation on the track.

What kinds of powers do the transformed abberations have? Have you worked in some templates/theme from the DMG2 or are they standard creatures?

This is a golden opportunity to torture the character - it is your DM duty to do this!!
 

Give her a cool new power related to the transformed abberations and then slowly kill (or change) her, it may give her a bit of pause before taking the cure.

PC Friend: "You can't walk... and you're getting worse... "
Poisoned PC: "I'm getting...*better*! "

Apart from the social penalties of being diseased I would work a disease track, but only have her check at stressful moments - like combat. And have physical transformation on the track.

What kinds of powers do the transformed abberations have? Have you worked in some templates/theme from the DMG2 or are they standard creatures?

This is a golden opportunity to torture the character - it is your DM duty to do this!!

I've decided a sidequest involving the poisoned character in a "Poisoned dreamworld" is going to factor in at one point, where she has to hunt down the demon that is possessing all of these poor drider/scorpion/mantis folk. With the other players taking over the role of spirits in the land of the dead (this is also a way to introduce a new PC, actually, so I'm killing two birds with one stone).

Before that, I'm going to introduce the "Can't sleep" thing, which will be kind of interesting, and probably a little creepy. I don't really want to implement too many drastic physical changes, but they'll be there.

I also don't really want to mess with the PC too much. I have been warned by the player herself that "I'm a girl, and could you give me an advance warning if you're going to kill my character, so I can prepare myself? I cry when PCs die..." And that's not really something I want on my shoulders. ;)

To answer your questions about the creatures... I mostly just throw open the PHB, grab a monster of roughly that level, and refluff to taste (change all damage types to poison, and often add in an ability on the fly). I'm too lazy to make my own monsters (plus I have no printer at this point...)
 

I'd go with compound eyes and give some added perception bonus due to the wider field of vision.
 


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