Hmm... let's see...
The big NPCs are concerned with their own problems, they are only use occasionally as information sources. Khelben was an exception, he gave the PCs a few orders, since they were members of the Tel'teukiira (Moonstars). I have psionics in the Realms in the form of the Society of the Mind. They used to be the Society of Mentat, but a long term campaign saw the group split into the Church of Mentat and the Society of the Mind. The Church of Mentat is gone, having been to radical and jeopardizing the weave. Hmm... other than that, I'm pretty into the Realms and like what the printed material has to offer. That said, I generally prefer my 2nd Edition source material over 3rd edition, with the exception of the FRCS, Silver Marches and Lost Empires.
Oh, and I too use the Great Wheel cosmology as a more "accurate" map of the planes. I like the new one given as sages working out through planar pathways, all the realms of the gods of Faerun, all the while not realizing that these places are actually within the Great Wheel and that there are other ways to go about the place. Really works with the whole clueless prime bit from Planescape.