I'm a newbie DM (an intermediate to fairly experienced FR player though) and have just started a solo-campaign with a newbie player (never played DND in her life). Here is what I have done with my FR campaign so far.
What I have done is pick a very small area for her to game in, roughly 2 miles long and wide. I chose the area of Dancing Falls within the High Forest. It is a very small area consisting of only 3 inhabited buildings: a small shrine to Selune (2 residents), a monestary of the Monks of the Old Order (2 residents, 1 of which is the PC), and a wizard's tower (1 apprentice house-sitting). There are nearby dwarven ruins for dungeoneering, with a few other "dungeons" in the area my player hasn't discovered yet. The shrine is for healing and the home the NPC cleric that sometimes adventures with her. The wizard's tower is where she can go to get any magic items she finds identified. The monestary is her home base where she can rest for the night.
I am finding that alot can be done in such a small area.
I've taken alot of advice from previous posters. Here are a few things I have done to try and give her the "flavor" of the realms.
1. I read up on the area of the High Forest and told her a brief overview of what she would probably know about the surrounding area.
2. She has been exposed to the religion of Selune as a result of the shrine as well as the Monks of the Old Order, both from the FRCS.
3. The NPC cleric of Selune has told her a brief "religious" story detailing the battle between Shar and Selune, resulting in the birth of Mystra.
4. She has encountered a patrol from the local tribe of centaurs that live within the High Forest and has heard about the nearby settlement of Ghosttree and the human settlement's of Noanar's Hold and Olisten's Hold.
5. She is on friendly terms with the local Dryad, who has told her a bit of history regarding the fall of Hellgate Keep.
I've only run a few sessions so far, but I am learning a lot about introducing the "flavor" of the realms to my player. One thing I am discovering though, is that it may not be a good idea to "force" your player to read FR literature unless she wants too.
Hope this helps!