Sure. First of all you've got to realize the example I offered is excerpted from a ~30 page adventure I wrote. So, from my example, let's take the "weakened" clue (the vampire is weakened from recently casting the Dark Gift of the Undying ritual).
The PCs enter the vampire's lair (the vampire is not there), following a lead from an NPC, and face the vampire's minions and gargoyles within.
They find the vampire's journal in which she ponders turning the NPC's father into a vampire via the Dark Gift of the Undying ritual, and contemplates that the ritual will leave her in a weakened state for several days, and how she might deal with it. Since the PC's already know that the vampire tried to turn the NPC's father (the clan's Pathfinder), they'll realize the vampire is weakened.
Back at the vistani camp (where all the suspects are), the PCs investigate the five suspects:
- Ahmesar is a spry vistani fiddler, seemingly possessed of supernatural vigor. So he probably isn't the vampire.
- Kessia is weak from the strain of maintaining ritual wards around the vistani camp during a time of heightened supernatural activity. She seems sincere enough, or is this merely the perfect cover?
- Valiora is an old frail tiefling woman, so it would be hard to tell if she is weak from casting a ritual or just because of her age.
- Sornryn is a drow lover of the NPC who is helping the PCs, however he has been accused of diablerie and chained to the bottom of a well; in his current state he is extremely weakened. Then again, if he's a vampire he could just turn gaseous to escape his chains...
- Wastrel is a grimy halfling fence who suffers from a wasting disease which has left him disfigured. Is his weakened state truly the result of the disease or has he been casting naughty magic?
So the PCs rule out Ahmesar as a suspect (at least for now), then go about acquiring new clues, until through process of elimination they find the vampire. Of course, they might go after the wrong suspect or fail to catch the vampire in time, in which case a "horrific reveal" may be in order.
Their investigation of the vampire is structured as 3 connected skill challenges. These skill challenges provide extra helpful information and context - they aren't strictly necessary to solve the logic puzzle. Investigating the suspects is the 2nd skill challenge...
While asking around the camp, the PCs learn that Ahmesar harbors a grudge against the clan leaders, particularly the Pathfinder, for abandoning him and his brother in the Shadowfell during the last Long Road. Some of the PCs are suspicious of the sly Ahmesar (even though he is the only suspect who *isn't* weakened), and dig further.
The PC bard tries to trick Ahmesar into revealing his secrets over a game of cards and wine. Succeeding his Bluff check, the bard coaxes Ahmesar into revealing the story of how his brother was “cruelly” abandoned by the Pathfinder in the Shadowfell during the last Long Road because the opening had become unstable, though he is evasive about how he escaped. The bard gets the sense that Ahmesar's guilt over his brother is stronger than his resentment toward the Pathfinder.
Later on, the PC rogue, who noticed Ahmesar is conspicuously absent during the day, follows him at the crack of dawn. Succeeding her Stealth check, the rogue follows Ahmesar to a gnarled lightning blasted oak tree where he speaks a command word "Far bulaz" and the tree splits open, revealing stairs descending into hellish red light. Ahmesar descends below.
So the PCs now know about Ahmesar's motives, and that he is involved with some kind of nefarious magic, but so far it seems unrelated to the vampire.