Majoru Oakheart
Adventurer
do you have to play all in one area/region? or is it okay if your character jumps from location to location if the next adventure happens to be a few cities over?
You can play in all the regions within the rules of LFR. In fact, you kind of have to in order to get to high enough level to play in the 2nd adventure in each region.
The adventures are written assuming you play them in almost any order. Of course, if the disconnect of playing one adventure in Akanul followed by another one in Cormyr with nothing in between is too much for you, you can always modify the adventures in order to provide reasons to travel from place to place. I'm sure you could make a fun campaign out of them.