Some of the substance changed a bit - eg angels end up being a little different in their core game backstory compared to W&M.I get the impression some of the stuff in W&M never made it into 4e.
My personal all-time favorite is 1st ed. Legends & Lore.
A book with Asgardians AND Arthurian heroes? Count me in!
2e. Monstrous Compendium was indeed pretty rad, and a welcome relief after those horrible three-ring-binder thingies.

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.