Well, we use exploding dice, so the way it would work would be like this.
Suppose you're a 3rd-level fighter with a total attack bonus of +7... you roll a natural 20! Hurray! Now you get to roll to 'explode'- and you add what you roll to your attack roll. So far you're hitting AC 27- hey, another 20! That means you hit AC 47! And you explode again- let's say you roll a 5. Your total to hit roll is 52.
Now roll to confirm.
What happens if you roll a natural 20 to confirm? You explode again! It really only matters when you're fighting something very hard to hit, though.
You explode downward on a natural 1 too. So let's say you roll a 1, followed by a 20- hey, that's a -12 so far (for our hypothetical F3)... and you explode further down. So if you roll a 10, your total to hit is -22. Ugh, even an ooze is going to get missed at that point!
Obviously, exploding dice replaces "always hit/miss on a natural 20/1"... we apply it to every d20 roll that is out of character (i.e. when the party divvies up loot by rolling off, they don't explode).