I highly doubt it would or will be made into a rpg game, but if it ever was I would be one of the first people to buy it.
I think its possible to make it, especially if you have the Confederation Handbook along with the novels and take it step by step, and use the various starship creation books out there (Neo's Starship Creator book is the best I have seen for science fiction) and use that for the various types of starships.
I think its also daunting because of just how vast the universe he created is and the detail he has put into it. I don't know of any other series written by a person that has that much detail about so many different things, its simply amazing. That said, I don't think Peter F. Hamilton would be against it being used as a d20 game (heck, it might shock the hell out of him if it ever was).