Cerebus Syndrome
The effort to create character development by adding layer upon layer of depth to their characters, taking a character of limited dimension (or meant to be a joke character) and making them fuller and richer. The idea is to take what was fun on one level and showing the reality beneath it. 'Cerebus Syndrome' refers to Dave Sim's epic, sometimes tragically flawed magnum opus, Cerebus the Aardvark. Cerebus started life as a parody of Conan the Barbarian starring an Earth-Pig born. Over time, it grew extremely complex, philosophical, and in many ways much much funnier. Then, Dave Sim went batshit crazy and Cerebus went straight to Hell, but that's for another day. People saw how Cerebus's humble roots could lead to glorious heights, and as cartoonists get bored with what they're doing, they decided to pull a Cerebus of their own.
Boredom is generally the key to a Cerebus Syndrome attempt. After a while, even a successful webcartoonist gets tired of fart jokes and sight gags and wants to make these characters more than they've been.
It is extremely hard to take a light, joke a day strip and push it through a successful Cerebus Syndrome. Dave Sim did it in stages, and at least in the early days of the transformation brought massive amounts of Funny to cover it over. Done perfectly, one only realizes in hindsight that the strip has turned out to be quite different than it used to be. Done sloppily, the Cerebus Syndrome fails, and the webcomic enters First and Ten Syndrome. Unfortunately, a failed Cerebus Syndrome is an excruciating process for the webcomic's fans to endure.
Please note that one can continue to bring the Funny while going for Cerebus Syndrome -- and in fact, probably should. It is far more common to drop the Funny, which increases geometrically the chance to fall into First and Ten. Note also that not all strips that bring heavy Story, mix humorous and serious elements, and have bad things happen to their characters are undergoing Cerebus Syndrome (or First and Ten Syndrome, for that matter). It's only those strips that began on a very light, even limited dimension level and then transform into something different that really shoot for the Cerebus Syndrome. So, Sluggy Freelance, which started out mostly humorous and now has a healthy dose of the Funny and the Story (with occasional forays into sequences like "Fire and Rain") is that rarity of rarities -- a successful Cerebus Syndrome. Digger and For Better or for Worse, on the other hand, had complex characterization from day one, and cannot be said to be in Cerebus or First and Ten. Got it? Good. There will be a quiz.