Our group takes kind of a wussy attitude toward that. We don't permit evil characters and it is incumbent on the player to create a character that would tend to be in a group. We still get some pretty neat characters out of that. I'm playing a fighter/rogue that has already met the PrC qualifications for Hospitalar and Blackguard (well, I'm not evil, but alignments can always change). If I go Blackgaurd, I automatically become an NPC and build a new character.
We do not allow evil PCs. And we all try and design a character that would work in a group. (No anti-social hates other but I am stuck in this group PCs) And we tend to design our characters to be more than just mercs out for gold. Yet we still end up with some conflict , like what to with goblin prisioners, baby kobolds things like that. Some of it is me I cannot stand doing things I know my character would not just because it is in the best interest of keeping gaming harmony. To me that takes the fun out of the game. If I play a paladin I am going to play the paladin lawful good and if that means standing up to the party over something I see as evil then so be it.