.....in terms of a hook, which is what it seems like you're looking for, the Golarion setting would fit into the "generic D&D" category, whatever that is. If you want to look at just the contents of the setting and ignore the quality, you're missing a huge part of the world. For example, Cheliax is a nation that has been overrun by demons. That one-sentence description doesn't make it sound like anything different from a dozen homebrews that have something similar. It's the high quality of the presentation and adventures in that region that set them apart.
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Basically, Golarion is a huge D&D playground, where there are dozens of interesting places and hundreds of different adventures. The same could be said of many other settings, both published and homebrew. What Golarion offers that many other settings do not is high-quality, innovative writing and adventures. If you want to ignore that quality, you're ignoring a huge part of that product line's appeal.