I would love to see pre-painted plastic minis. The quality can be like Mage Knight; from the little I've seen, they look like they'd do just fine. I see these as inexpensive alternatives to pewter. And when I say inexpensive, I'd want to pay less than a buck a figure. After all, these would be the hordes the PCs fight against.
If they go the collectable CCG route, I'm right out of the running. I refuse to buy those.
If I can buy a pack of a dozen orcs for $9.99 or less that could be my price point to pick up several sets. Different looking orcs would be nice. So would a way to determine numbers, like a clicker base or even painted on the base, whichever is cheaper. I would suggest doing packs of monsters in the half dozen and dozen variety. For less common monsters, group them in sets of six by monster type. For instance, pick 6 abberations and sell them in a box for $4.99.
There's plenty of room in the market for these plastic minis. For those who prefer painting pewter, they already have a huge inventory to choose from with Ral Partha, Games Workshop, and others. I think the key is to keep them very inexpensive and encourage purchasing in bulk.
For those of us who like minis but aren't really interested in painting, this would be a great alternative.