I'm still on the consumer side of the board, not publisher, but I don't see legal reprintings of OGC as a (current) problem. I'm not aware of any competing versions of the same product, and I wouldn't support a company that engages in such practices. I'd assume that the title and credits are not OGC -- assuming those pages are included in the main document, that alone prevents a casual copyist from simply reposting the document to RPGNow. Once you get into having to strip off the title & credits page, it's not a big leap to simply grab all the text, create a new document, and send it along to RPGNow (who will send it right back with a big no thank you anyways).
As you've noted, you aren't going to stop (or even slow down) the pirate, and you aren't going to defer the guy handing out a few copies to his gaming group -- he's not looking for profit, he's not posting them on the internet, and he's not worried about legality. Morality, maybe, but not legality.
Frankly, if I were to do something like this, I'd pick on the big sellers. Librum Equalus anyone?
On other related topics...I'd include border art, just because it looks pretty. B&w, pen & ink style, some knotwork or something. Nothing heavy.
As far as culling OGC into a separate document -- I think it's a good thing. It removes all question of OGC, and rtf is simple to deal with. I read the product for use, but when cutting out OGC, I'd always look to a txt or rtf version first.
Cheers
Nell.