Ive used sandblasters for both pottery and car respraying and I cant really say that the gun-type with high pressure water would be a good way of offing anyone, unless they hold really still and you have a few hours to spare.
It will be delightfully painful though.
Yes, grains of sand at high velocity could kill someone. However the types of velocities youre talking about are in many 1000's of metres a second as by itself the grain of sand has very little mass, maybe 0.001gms by itself, which is why you need it to go at km's a second to do any real impact. Sort of like the velocities you get out of space junk in orbit, little paint flecks from previous rockets moving at 15km/s do a great deal of greif much like a conventional bullet.
But, youve got to basically make some kind of mass-driver to accelerate a lot of bits of sand, which could be done, why you wouldnt take the approach of a chemical+bullet or a high energy maser or laser to do much the same thing except the projectiles are different sizes and much easier to manage.