For those advocating to throw something at them anyway, isn't a big part of the idea of a sandbox that the characters are choosing what to encounter. If it's a magician's force of "either pick one of these places I have already picked, or pick somewhere else and I'll pick for you" - it seems to go against giving the players choice that that defines a sandbox vs. more traditional play.
Sandbox does not mean free from the consequences of prior choices or actions.
If the players angered someone powerful enough to pursue them, then the players should be pursued.
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