Radiating Gnome
Adventurer
I'm extremely impressed with how well it would work for fantasy out of the box. (To be honest, I'm impressed with how well it would work for most genres out of the box.) About the only limitation seems to be that almost no matter what you do, it's going to be a tad "pulpy." And that's great with me!
Probably one of the biggest differences is the idea that in a lot of cases the game will feel sort of "swingy" -- a lot of attacking and rolling damage but only occasionally having anything to show for it. Especially with high toughness targets. I've been doing some "practice" sea battles for my "Pirates of the Spanish Main + Horror" game, and what you end up with is a couple of sloops sailing around each other banging away on their guns waiting for some lucky dice to explode.
But with so much less bookkeeping, it's easy to stay focused on the game and keep things moving.
-j