Ultimately, I believe the "rolled stats" issue is a red herring: They've already mentioned they will have non-rolled modules for point buy and this issue has been a solved problem since 3.x that I don't see them regressing on.
I truly hope so, because I've played in a few AD&D/3E campaigns in which my best stat was 14 or 15, and another guy had that as his lowest stat (and DM always supervises rolls, so there was never any cheating involved). If they are going to further emphasize the importance of ability scores, point-buy works far better in terms of balance, even though it usually does encourage stat optimization.
I can live with DA-style focuses, although I hope there will be some sort of official skill/focus list. I'd still prefer 4E/PF style skills that were divorced from stats; for example, if I search a wall for secret doors, my rogue could add his Dex bonus to Perception (using his sense of touch to "feel" any cracks/outline of a door). Or you could use Con for Nature/Survival/Athletics when you're trying to outrun opponents in a forest.
I am concerned about saving throws, however; seems a bit too open-ended for me, and I don't think it's necessarily a good idea to have 6 saving throws in the game (or randomly roll the DC). Playing the Devil's Advocate here, if the wizard can use Int saving throw to escape grapple, why couldn't your fighter suggest Str or Con against Fireball (or, practically, every spell)? Or could you, perhaps, also use Int, saying "My guy is so bright that he *so* could see that fireball coming, so I want a Spellcraft check to get me an Int or Wis saving throw -- besides, I told you I was hanging outside the room, didn't I?" What does this "clever/good play" Monte mentioned mean anyway?
Honestly, what was wrong with 4E Defenses? Besides, I don't see any problem using the 3E/PF saving throw system alongside Defenses... if you get hit by a condition, "save ends" would just become "save ends (Fort DC X)", or something.