Str - spells that seek to physically restrain the target (breaking/escaping a resilient sphere, evard's black tentacles, web, perhaps certain wall spells)
Dex - spells that can be avoided via quick reaction (AoE such as fireball and lightning bolt)
Con - spells that attack the body (Disintegrate, Cause Disease, Polymorph)
Wis - spells overcome by keeping a cool head or "grip on reality" - fear, insanity (this would make clerics good vs. fear, falling back on their faith in a deity)
Int - illusions
Cha - charms and domination
I'm very tempted to use exactly this system as a house rule, but I'm concerned about possible impacts on game balance. Does anyone have any thoughts on what the impacts would be (for good or ill)?
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