Dude, I have to question your choice there. The Chosen of God Paragon Path / PrC is ridiculously overpowered, and like old-school Forgotten Realms, the NPCs are so powerful it makes you wonder why the problems haven't been solved by them already.
My group is also not very good at following rules set down by authority figures, so they usually run afoul of the Ten Commandments on multiple levels. All it usually takes is a visit to the tavern and they've violated three or four. My PCs think we should just hand-wave them away, but I think that you really lose the flavor of the setting that way.
I also am not fond of the level of deity intervention in that setting. I understand that in the later setting material it's not so blatant, but you did specifically mention the Bible here, so that's what I'm going off of.
The final nail in the coffin for me, though, is the lack of character options. Most of the races just aren't there, and everyone seems to want to play as Gods Chosen People which IMO are poorly balanced, with numerous benefits but mainly roleplaying restrictions to balance them out, like 2E drow. Also, I'm a big fan of arcane classes, and the way the setting is structured it's basically impossible to have a divine and arcane character in the same party, since the divine users won't suffer the arcane ones to live.
However, to each his own!