Let's check:I think you’re assuming that change to a setting means it’s broken, and that’s a mistake. If you look at what @Vraal said, Spire is set up so that things… consequential things… are about to take place. Things are going to change.
I don’t think that’s the same as “breaking” the setting.
Glad someone mentioned Spire, I was going to as well but for a different reason. I can't remember where I first encountered this analogy, but I think it's a good principle of worldbuilding for this medium: set up your world so that it's a powder keg about to blow.
Spire is a great example of this. The setting is incredibly detailed (some might say too detailed), but everything's constructed with player engagement in mind; the city's absolutely packed with fuses to light. Even if the action of the campaign is confined to just a single district, you've got extremely good odds that after a few sessions, much of the setting, if not all of it, will never be the same again.