From what little facts we have so far we know there 8 classes covering 4 roles, thus 2 classes per role. From the classes that have been mentioned...
Defender: Fighter, Paladin
Leader: Cleric, Warlord
Controller: Wizard, Sorcerer
Striker: Rogue, Ranger
Warlord has been spotted in the D&DInsider screenshots and in the GamerZer0's interview with Wyatt. it is likely the replacement for the Bard. However, I believe this may also have beaten up and taken on some of the Barbarian's shtick.
Sorcerers have specifically been said to still be around but that they will be different than Wizards. It has been stated that they will not be merged and that they will have bigger differences than simple resource management issues.
This is the PHB combination of classes I'd be betting my money on right now. However, I do not think that Paladin is going to be the class of old that people expect. It has already been stated that alignment is no longer restricted to LG. I believe this may indicate shades of the Unearthed Arcana "flavors" of champion paladins (LG, LE, CG, CE).
JMHO. YMMV.