Themey delicious
I ran a cold war/imperialism game once. The world was split by conflict between an Orcish Khanate, brute force, and a Gnomish Imperium, magic and finesse. Both nations operated on a level of power that was unimaginable to other nations expect for when they recieved gifts or aid from one side or the other. Citizens from these nations were effectively more powerful than local governments and had no compunction about pushing people around except where the other power might interfere.
The players were all characters from 'third world' nations or nations allied with the Gnomish power, and were part of a massive colonial expedition to a previously unknown continent sponsored by some of the more powerful third world nations with help and advisors from the two superpowers scattered throughout the whole operation.
As a DM it was the most fun I ever had. The players were free to whatever they wanted in the 'new' world, more Australia then the Americas, but whenever an Orc or a Gnome showed up they were suddenly all finesse.
I also liked it because I was able to deal with fairly contemporary issues from a very different perspective and still preserve a very fantasy feel. And the Gnomes were bad asses. Despite being good, the players were frightened to death of them.
The game never reached fruition, sadly, as this was played just as 3E was coming out and everyone wanted to play. Eventually we had 12 players and that only worked for so long. Still a lot of those players refer to moments during the game as the best role-playing experience they ever had.