It's awesome to see almost everyone voting for a turn-based game, which is what I've wanted from most of these titles. NWN and company have been kinda fun, but don't really feel like D&D as much as they could. The fast pace also means that you end up fighting a gazillion Orcs for 8 experience points each, which isn't nearly the same as a standard D&D game. The 4E rules have the potential to be interesting enough on their own to translate almost directly to a tactically-oriented computer game, but... it might not work out quite as well in practise as it does in theory.
Either way, I'm sure we'll all let out a collective groan when Bethesda announces its first real-time action/RPG based on the 4th edition rules.