I'm with trancejeremy on this one. I like a more realistic view of Earth's future. I think the best sci-fi setting yet has been the Heavy Gear books from Dream Pod 9. I like the feel of space travel being dangerous, ala HG and Firefly; not high space fantasy like Star Trek and such.
If there was a new setting, I would like to see the following:
1) Gritty, dangerous space travel.
2) An easy method of resolving ship-to-ship combat.
3) Advanced technology, but at a still foreseeable level. using D20: Future's PL's as an example, I'm a big fan of PL6, with some of the cutting edge technolgy being from PL7.
4) Plenty of locations to explore that can be easily utilized in a campaign.
5) There is no NEED for aliens. If they are included, make them subdued, not over the top.