Way back in Pyramid Online, Ken Hite wrote five supers seeds set in historical periods:
Marvel Heroes in Imperial Rome
DC Heroes in Renaissance Italy
99 Muslim heroes - one for each name of Allah - in the Crusades
Civil War
Indian Wars.
Each one sounded great.
"The alien craft fell to earth in 1452, rocketed from a doomed planet. Raised in the small village of Vinci by Gianbattista and Marta DiChiente, Calli learned to fight for truth, justice, and humanitas -- now he is the metropolis of Florence's greatest defender, the Star. (His childhood playmate, sadly, has become a twisted genius bent on revenge -- feared artificer Leonardo Lector.) Each city has its own brightly-caparisoned hero, complete with secret identity and superpowered nemeses. The Raven hunts criminals in the back alleys of Rome, while serving on the Curia by day as a wealthy noble cardinal. Chain Lightning runs criminals and condottieri ragged in Pisa; the Emeraldist joins him when Milan is quiet. The Atlantean patrols the seas of Italy from an under-water palazzo beneath Venice. Silver Athena dispenses justice (and protects women) while ruling an island of Amazons near Sicily. Occasionally, all these heroes team up in a Legion of the Just, sponsored by enigmatic politician Niccolo Machiavelli -- usually to defeat invasions from France, Spain, or Venus, but sometimes to foil the plots of villainous alchemists, mercenaries, gods, and so forth. Slowly, the Legion is uniting Italy -- how will that change the world?"