I'd like to see the portability and graphics of a Nippon Ichi game combined with the mechanics and storyline of Final Fantasy Tactics. Nippon Ichi makes great TRPGs, but the story is never as developed as FFT. Meanwhile the FFT property was used to push out the mediocre and somewhat poor FFT-Advanced.
I definitely could stand for a privateer/wing-commander/tie-fighter/x-wing type game.
I'm also a fairly big fan of Mechwarrior and mecha games, and they've all been somewhat failures for me. I'd like to see something bigger budget.
With MMO's, I'd like to steal some of Tabula Rasa's ideas, but build it within a universe that people will understand better. I think the idea of an Eberron MMO sounds fun... though we've already 'technically' got one. Of course, D&D online comes short of how I imagine Eberron by a long shot.
I still crave Diablo 3, or for what it takes a dark fantasy RPG that's easy to pick up and play for short sessions.