You know, I bought quite a few of the random minis, mainly because I liked getting oddball ones that forced me to be creative in order to use them. I would have preferred to get non-randomized minis, so I could get all the ones I wanted, but that was not possible from WotC. I bought a few singles, but then I started running out of room and spending money. Now I look for minis that fit my need. That means I am looking at non-random packs. I also prefer them pre-painted, mainly because I am allergic to the paints I would need to use to paint them. Reaper has started a good line, and I am hoping that the WotC line will work well too. I am not running 4e (though I will be possibly playing some), so my needs are mostly for older editions of D&D and other non-D&D games.
So, there are my thoughts on the topic. I look forward to seeing what they do. I hope it will be something I will want to get.