Cergorach
The Laughing One
I'm about to start a 4E campaign as a GM, and instead of going with the official 4E adventure path(s), I opted for converting Rise of the Runelords to 4E. It might be a bit more work then just running a WotC 4E adventure, but there's so much more stuff/fluff/background out for RotR. I was looking for something that was not a campaign setting my players knew (of), but something that was well supported, PAIZO makes that happen with their Pathfinder line.