The Video goes over some interesting points:
Backgrounds are now "Custom default" with your choice of stat boosts and a level 1 feat.
Feats are now separated into levels, level 1 feats don't have stats, higher level feats can have a +1 bonus for a stat in order to soften the blow of having to pick between ASIs and a Feat.
Crits are a player only thing, with spells not being able to crit, effectively Martial only.
The spell lists are going to be split up into Arcane, Divine, and Primal. Classes will pick one of the lists and have additional spells added to their lists.
Races are going to get new options.
Inspiration is going to be reworked so that the DM doesn't have to remember it all the time.