My issue is that, having played countless RPGs over 30+ years, and having found relatively lighter ones with less prep play pretty great, I probably wouldn't want to run D&D without digital tools supporting it. They've been really helpful for my main group particularly. I'm not just talking about VTTs, but a probably integrated character builder, searchable rules databases, and so on. Currently for 5E only Beyond offers that (4E's offering was slightly better, weirdly, in terms of what it could do, but was much clunkier-looking and relied on Silverlight lol).
Without all that, I'd be willing to play D&D, but I wouldn't be willing to run it. Also, all my 5E "books" are on Beyond, because I don't have space in my stupid London flat for a whole ton more books. I haven't bought a physical RPG book for like, four or five years? Maybe longer.
On the bright side, I haven't got a bunch of 5E adventures/campaigns I want to run, because I've largely run my own campaign/adventures in 5E (like 4E), so it's not like I'll be stamping my foot and cursing!
So I think my main idea would be to just run a different game. Maybe PF2, maybe Worlds Without Number, maybe DIE, who knows!