Having recently started a new 5E campaign, I was reminded how empowering it is to get out the machete and start cutting away anything that doesn't fit into a campaign. Yeah, you could have everything in the books in a setting (I run a Ptolus campaign that does, for instance), but much of the time, campaigns are improved by having focus.
Having a lot of optional stuff is very empowering in that regard, because once you start chopping the other stuff away, you can end up with something nicely customized for the kind of game you want to play.