Just like D&D 4, a Pathfinder 2 adventure feels not like D&D, but specifically D&D4 and PF2 respectively. That is, you need to set up a PF2 adventure specifically as such, as evidenced by Paizo's adventure paths - they clearly come across as PF2 adventures, not very useful for general D&D usage.
That's the core of these systems' downfall. It just doesn't feel like D&D anymore.
So I've been running 4E weekly for about 6 months now - and another group of PF2 weekly for over a year.
Here's my take. Both systems basically have well-balanced encounters, and you can't balance encounters without an assumption of the power of the characters. That means there is a baseline of power among all the classes & most abilities reset between encounters.
This leads to a feeling of a miniatures skirmish game - like Warcry, Mordheim, or Necromunda. However, what makes those games enjoyable is that for most battles - both sides are evenly matched and its competitive.
Where this style of play breaks down for RPGs like 4E or PF2, is that you're probably not playing your skirmish game 4-5 hours a session every week for more than a year. And the resolution of the battle isn't a foregone conclusion. In 4E and PF2, a GM is supposed to offer a thrilling tactical experience that gives the illusion of danger, but clearly the party is going to win 99.9% of the time with the loss of 25% of its resources.
To me, this gameplay loop feels soulless and repetitive. It's been a major source of my burnout - I feel so limited in my creativity.
I can't run a mystery in 4E - all the monsters are designed to be balanced, defeated in a combat with 2 skirmishers, 1 brute, 1 solider, and 4 minions (or whatever). Sure, I can run a Skill Challenge to discover the identity of the Lycanthrope hiding in the village - but is the party going to feel any threat to their characters when confronting him? And if they don't feel that threat in the combat, how can the lead-up investigation have any tension?
In PF2E, save a Hero Point and you're immortal. At the end of the fight, take 15 minutes and you're back to full HP.
There are no consequences in these games.