the key to Interlock as a system is that each Interlock game is an adapted core, much like how 2d20 and YZE games are... the procedures are similar within the system, with the attributes and skills scaling the same, the attributes are mostly the same, but everything else is subject to change.
One can easily cross-use critters and such, but the damage rules differ strongly
Mekton II and Mekton Zeta have a different damage scaling than CP 2013/2020.
Both are different from the Interlock end of Fuzion games (which I only recall a couple).
TFOS/Star Riders is a third damage scale, and also uses a d6 for rolls instead of a d10...
I have used CP2020 + Night's Edge + Mekton Empire (psionics rules only) for a CP one-shot shadowrunish feel... it worked fine, but I converted 1 Mekton DP to 1d6 CP damage.