Disagreements
Okay, I have to mildly disagree with #s 16 & 30, and more strongly with... was it 19?
ALL PCs (except Cleric, who usually can't) should have four weapons, usually... A Slasher, a Blunt, a Missile, and a Piercer...
As Zarathustran points out, armor spikes and/or spiked gauntlets will work as piercers, but so will a dagger. Strap the latter to your thigh, so it will be resting againt your hand when it is at your side. When swallowed or grabbed, this will be all you can use. If your GM will let you, have an armourer make claws for you (1D4+3, in our games) which go on a plate fitting over the back of the hand, are similar to spiked gauntlets, and require no Exotic Weapon Proficiency.
Blades and blunts are for creatures which take less damage from the other (Skeletons, for instance). Besides, cutting a rope with a mace is tough!
If you're a Rogue and can't afford the weight, take the Morningstar, and use it two-handed for the 1.5x STR bonus.
As the great Z-meister hath said, EVERYONE needs a missile weapon!
Magely sorts do well with Quarterstaff and TWF, especially if it's unshod and a friendly Druid casts Shillelagh on it! (YOWch!)
For fighterly sorts, forget taking a blunt weapon, and use the crowbar as a club. Even if the GM makes you expend an Exotic Weapon Proficiency (as in 2e, where it did 1D6+1), it is still worth it, and lighter than a mace.
Now as for (was it #19?), attacking the most powerful enemy first, I have to disagree! If you walk into a room with a Kobold Mage, a Huge Red Dragon, and a Bugbear Cleric, kill the mage, first. If you attack the strongest NPC, it will take many rounds to die. If you take out the Kobold first, he will not get the many rounds' worth of free attacks. Frankly, in this situation, dividing fire between the Kobold and Bugbear is probably the better idea. Both may drop in the first round.
There are times to use either tactic. If the dragon is with a host of warriors with no missile weapons, then toast it until the men start getting to you. Knowing when to attack the biggest threat, and when to take out the low-level ones, is something that requires some experience. It is VERY context-dependent!